Post by Admin on Jan 7, 2023 11:25:33 GMT
This is about the condition that is commonly called "Morgellons". Also called "Fiber Disease" and promotion of that narrative has caused people to have no sense of direction. Without a good diagnosis how can a person get relief? An appropriate diagnosis would be carcinogenic cutaineous vasculitis. Bartonella infection causes the kind of cancer that is Cutaineous Vasculitis with fiber production and Fiber Production is a common phenomena in a variety of cancers. This carcinogenic cutaineous vasculitis can be successfully treated.
www.ncbi.nlm.nih.gov/pmc/articles/PMC3383535/#:~:text=1990%5D%2C%20cutaneous%20vasculitis%20appears%20to
“Malignancy Risk in Vasculitis”
"cutaneous vasculitis appears to be the most common vasculitic manifestation of cancer"
Quite a fuss has been made about the fibers by various groups and filament rearrangement is a common characteristic in a variety of cancers.
www.nature.com/articles/srep45152
"Intermediate filament reorganization dynamically influences cancer cell alignment and migration"
www.ncbi.nlm.nih.gov/pmc/articles/PMC6562751/
“Intermediate Filaments as Effectors of Cancer Development and Metastasis: A Focus on Keratins, Vimentin, and Nestin”
“Intermediate filament (IF) proteins make up the largest family of cytoskeletal proteins in metazoans, and are traditionally known for their roles in fostering structural integrity in cells and tissues. Remarkably, individual IF genes are tightly regulated in a fashion that reflects the type of tissue, its developmental and differentiation stages, and biological context. In cancer, IF proteins serve as diagnostic markers, as tumor cells partially retain their original signature expression of IF proteins. However, there are also characteristic alterations in IF gene expression and protein regulation.”
Well if you have “characteristic alterations in IF gene expression” That is because of an induced mutation.
“A growing number of studies are showing that altered expression of a subset of IF proteins might contribute to patient prognoses [27]. This is most notable for vimentin, which is upregulated in cancer cells that have undergone EMT [15]. A number of keratins also exhibit altered expression in various tumors compared to the normal tissues”
“It is clear that alterations in the expression patterns of IF proteins are correlated with inflammation and tumor growth. The extent to which these altered expression patterns directly influence inflammatory gene expression and immune cell recruitment to tumor tissue environments have only recently emerged. Given the tissue- and context-dependent expression patterns for IF proteins, it appears likely that additional IF proteins (particularly the large family of keratins that can be robustly altered in epithelial-derived tumors) play a direct role in modifying inflammatory microenvironments.”
“Going forward, it will be important to determine how different intermediate filament proteins present in a given tumor coordinate their functions to affect tumor progression. Not only are several keratins present in the same tumors, but in certain cancer types, vimentin is co-expressed with keratins [13,14]. While different intermediate filament proteins, such as vimentin and keratins, assemble into separate filament networks with different dynamics [157], these two intermediate filament networks interact and are involved in a crosstalk [158], which plays a critical role in cell migration [27,159]. Due to the context-dependent expression and roles of intermediate filament proteins, deciphering how various intermediate filament proteins cooperate or antagonize each other’s functions would have valuable prognostic value for cancer patients.”
academic.oup.com/jid/article/207/9/1397/928803
"Depolymerization of Cytokeratin Intermediate Filaments Facilitates Intracellular Infection of HeLa Cells by Bartonella henselae"
"B. henselae Infection Stimulates the Increase of Keratin Gene Expression"
O.K. is this starting to sound familiar?
We know that Bartonella causes cancer;
nbprotocol.proboards.com/thread/598/bartonella-cancer
And we know that Bartonella causes vasculitis;
nbprotocol.proboards.com/thread/577/bartonella-vasculitis
And we know that Bartonella induces an array of mutations;
www.pnas.org/content/108/35/14643.abstract
“Conjugative DNA transfer into human cells by the VirB/VirD4 type IV secretion system of the bacterial pathogen Bartonella henselae”
“Bacterial type IV secretion systems (T4SS) mediate interbacterial conjugative DNA transfer and transkingdom protein transfer into eukaryotic host cells in bacterial pathogenesis. The sole bacterium known to naturally transfer DNA into eukaryotic host cells via a T4SS is the plant pathogen Agrobacterium tumefaciens. Here we demonstrate T4SS-mediated DNA transfer from a human bacterial pathogen into human cells. We show that the zoonotic pathogen Bartonella henselae can transfer a cryptic plasmid occurring in the bartonellae into the human endothelial cell line EA.hy926 via its T4SS VirB/VirD4”
And we know that Bartonella causes Cutaineous Vasculitis with fiber production.
How to treat that is in a link at the bottom of this next link;
nbprotocol.proboards.com/thread/273/fiber-production-skin
~d
www.ncbi.nlm.nih.gov/pmc/articles/PMC3383535/#:~:text=1990%5D%2C%20cutaneous%20vasculitis%20appears%20to
“Malignancy Risk in Vasculitis”
"cutaneous vasculitis appears to be the most common vasculitic manifestation of cancer"
Quite a fuss has been made about the fibers by various groups and filament rearrangement is a common characteristic in a variety of cancers.
www.nature.com/articles/srep45152
"Intermediate filament reorganization dynamically influences cancer cell alignment and migration"
www.ncbi.nlm.nih.gov/pmc/articles/PMC6562751/
“Intermediate Filaments as Effectors of Cancer Development and Metastasis: A Focus on Keratins, Vimentin, and Nestin”
“Intermediate filament (IF) proteins make up the largest family of cytoskeletal proteins in metazoans, and are traditionally known for their roles in fostering structural integrity in cells and tissues. Remarkably, individual IF genes are tightly regulated in a fashion that reflects the type of tissue, its developmental and differentiation stages, and biological context. In cancer, IF proteins serve as diagnostic markers, as tumor cells partially retain their original signature expression of IF proteins. However, there are also characteristic alterations in IF gene expression and protein regulation.”
Well if you have “characteristic alterations in IF gene expression” That is because of an induced mutation.
“A growing number of studies are showing that altered expression of a subset of IF proteins might contribute to patient prognoses [27]. This is most notable for vimentin, which is upregulated in cancer cells that have undergone EMT [15]. A number of keratins also exhibit altered expression in various tumors compared to the normal tissues”
“It is clear that alterations in the expression patterns of IF proteins are correlated with inflammation and tumor growth. The extent to which these altered expression patterns directly influence inflammatory gene expression and immune cell recruitment to tumor tissue environments have only recently emerged. Given the tissue- and context-dependent expression patterns for IF proteins, it appears likely that additional IF proteins (particularly the large family of keratins that can be robustly altered in epithelial-derived tumors) play a direct role in modifying inflammatory microenvironments.”
“Going forward, it will be important to determine how different intermediate filament proteins present in a given tumor coordinate their functions to affect tumor progression. Not only are several keratins present in the same tumors, but in certain cancer types, vimentin is co-expressed with keratins [13,14]. While different intermediate filament proteins, such as vimentin and keratins, assemble into separate filament networks with different dynamics [157], these two intermediate filament networks interact and are involved in a crosstalk [158], which plays a critical role in cell migration [27,159]. Due to the context-dependent expression and roles of intermediate filament proteins, deciphering how various intermediate filament proteins cooperate or antagonize each other’s functions would have valuable prognostic value for cancer patients.”
academic.oup.com/jid/article/207/9/1397/928803
"Depolymerization of Cytokeratin Intermediate Filaments Facilitates Intracellular Infection of HeLa Cells by Bartonella henselae"
"B. henselae Infection Stimulates the Increase of Keratin Gene Expression"
O.K. is this starting to sound familiar?
We know that Bartonella causes cancer;
nbprotocol.proboards.com/thread/598/bartonella-cancer
And we know that Bartonella causes vasculitis;
nbprotocol.proboards.com/thread/577/bartonella-vasculitis
And we know that Bartonella induces an array of mutations;
www.pnas.org/content/108/35/14643.abstract
“Conjugative DNA transfer into human cells by the VirB/VirD4 type IV secretion system of the bacterial pathogen Bartonella henselae”
“Bacterial type IV secretion systems (T4SS) mediate interbacterial conjugative DNA transfer and transkingdom protein transfer into eukaryotic host cells in bacterial pathogenesis. The sole bacterium known to naturally transfer DNA into eukaryotic host cells via a T4SS is the plant pathogen Agrobacterium tumefaciens. Here we demonstrate T4SS-mediated DNA transfer from a human bacterial pathogen into human cells. We show that the zoonotic pathogen Bartonella henselae can transfer a cryptic plasmid occurring in the bartonellae into the human endothelial cell line EA.hy926 via its T4SS VirB/VirD4”
And we know that Bartonella causes Cutaineous Vasculitis with fiber production.
How to treat that is in a link at the bottom of this next link;
nbprotocol.proboards.com/thread/273/fiber-production-skin
~d