Post by Admin on Nov 21, 2022 19:47:22 GMT
Here is a really good strategy to attack a Bartonella infection. The information on treating Borrelia is at the bottom of the page.
Iron is sequestered by cancer cells and cells infected with microbes and the presence of iron activates artimisinin's ferroptotic activity.
jhoonline.biomedcentral.com/articles/10.1186/s13045-019-0720-y
“Ferroptosis, a new form of cell death: opportunities and challenges in cancer”
“Researches indicated that ferroptosis could be triggered by diverse physiological conditions and pathological stresses in humans and animals. Ferroptosis is gradually accepted as an adaptive feature to eliminate the malignant cells. It plays a pivotal role in the depression of tumorigenesis by removing the cells that are deficient in key nutrients in the environment or damaged by infection or ambient stress”
“Ferroptosis is programmed necrosis mainly triggered by extra-mitochondrial lipid peroxidation arising from an iron-dependent ROS accretion”
Here Dr.Berg explains Reactive Oxygen Species;
Not enough iron in your system will cause cellular dysfunction like anemia and immune disregulation, too much is toxic but that would be way beyond practical limits. Iron deficiency in a person will cause artimisinin to not work as well.
Bartonella uptakes heme iron from red blood cells.
www.ncbi.nlm.nih.gov/pmc/articles/PMC95469/
“Identification, Characterization, and Functional Analysis of a Gene Encoding the Ferric Uptake Regulation Protein in Bartonella Species”
“Bartonella has an obligate heme requirement”
pubmed.ncbi.nlm.nih.gov/24151576/
"Bartonella genomes encode for 3-5 heme-binding proteins. In Bartonella henselae heme-binding proteins were shown to be involved in heme uptake process, oxidative stress response, and survival inside endothelial cells and in the flea. In this report, we discuss the use of the heme uptake and storage system of B. henselae during its infection cycle."
Taking an iron complex will feed the bartonella and will make Bartonella a target to be eliminated through ferroptosis. Also your immune system cells need iron to function well.
www.imm.ox.ac.uk/news/study-uncovers-how-low-blood-iron-diminishes-immune-response
“Study uncovers how low blood iron diminishes immune response”
In Ferroptosis cell lipids are attacked causing cell death.
www.nature.com/articles/s41419-020-2298-2
“Recent studies have shown that ferroptosis is closely related to the pathophysiological processes of many diseases, such as tumors, nervous system diseases, ischemia-reperfusion injury, kidney injury, and blood diseases. How to intervene in the occurrence and development of related diseases by regulating cell ferroptosis has become a hotspot and focus of etiological research and treatment, but the functional changes and specific molecular mechanisms of ferroptosis still need to be further explored.”
So what has come to my attention is the use of Artimisinin since Bartonella infection and cancer operate very much the same.
pubmed.ncbi.nlm.nih.gov/31114026/
“In this study, we found that artemisinin compounds can sensitize cancer cells to ferroptosis, a new form of programmed cell death driven by iron-dependent lipid peroxidation.”
The natural treatments that work against Bartonella are the ones that have anti-cancer activity because bartonella infection and cancer use the same pathways.
When I started to become interested in Bromelain I noticed that quite a few researchers were combining it with other compounds and whatever it was combined with became more effective.
One reason in this case is that Bromelain inhibits the main pathway that metabolizes Artemisinin so it stays in the blood longer and you can use a smaller dose of Artemisinin. The dose of Bromelain that you want to taper up to over a couple months is 35mg per Kg of body weight, that dose will prevent bartonella infection from advancing and that is discussed more in the link at the bottom of the page.
drbvitamins.com/products/doctor-s-best-high-potency-bromelain-3000-gdu-500-mg-90-veggie-caps-20961
pubmed.ncbi.nlm.nih.gov/18256496/
"There is limited information on the effect of fruits on human cytochrome P450 (CYP) 2C9 activity."
"Thus we found that pineapple juice was a potent inhibitor of CYP2C9, and that the inhibitory effect might be due to the bromelain contained in pineapple."
The above is called the "Bergamot Effect" and there have been warnings about grapefruit juice increasing the level of pharma drugs in the blood, but if your like me and don't believe in taking anything produced by pharma then that is nothing to worry about.
pubmed.ncbi.nlm.nih.gov/15761118/
"Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor"
"The major disadvantage of these medicines is the comparatively high recrudescence rate, which has been attributed to the remarkable decrease of artemisinin plasma concentrations during multiple dosing."
So to keep the plasma levels effective then taking it with bromelain works.
Artimisinin also shuts down NF kappa b translocation and that prevents further infection and creation of abnormal cells.
pubmed.ncbi.nlm.nih.gov/28000518/
“Then the artemisinin significantly inhibited the expression of NF-κB reporter gene induced by TNF-α in a dose-dependent manner.”
Adding this to the already Bromelain and Monolaurin based protocol will make it more effective.
This Artemisin works, when using the Bromelain and Monolaurin protocol you can take 2 capsules of the 100 mg capsule every day.You can increase that dose as you become more accustomed to it. Effectiveness is dose dependent. The target dose to work toward is 1 of 100g capsules for every 30 pounds of body weight daily.
drbvitamins.com/products/doctor-s-best-artemisinin-100-mg-90-veggie-caps-7592
When combining these items the result is an increase in effectiveness , synergy.
This Iron complex is a good one and available at quite a few sites.
www.integrativepro.com/products/iron-complex
The above strategy works well on Bartonella but you need Monolaurin to kill Borrelia and that is in the protocol as well.
www.sciencedirect.com/science/article/pii/S1084952120301993
"Given its exceptional chemical properties, iron plays an important role in numerous biochemical processes in almost all living organisms with only few exceptions such as Borrelia burgdorferi or some Lactobacilli"
pubmed.ncbi.nlm.nih.gov/26457476/
"In vitro evaluation of antibacterial activity of phytochemicals and micronutrients against Borrelia burgdorferi and Borrelia garinii"
"Conclusions: The most effective antimicrobial compounds against all morphological forms of the two tested Borrelia sp. were baicalein and monolaurin."
www.lauricidin.com/
Combining different strategies into a science based protocol is successful. When a person has these diseases and uses something that kills the infections and abnormal cells they create that will release a lot of toxins in the body and make a person feel pretty lousy. The longer you have been infected then there will be more toxins.A strong protocol will also cause this more rapidly. The NB protocol has items to address this, a whole protocol is needed to manage recovery. Read the protocol thread for that information.
One obstacle to success with a Bartonella infection is the calcification it causes which will prevent treatment penetration and that should also be addressed.
nbprotocol.proboards.com/thread/13/calcification
Read this next link to learn how to prevent bacterial adhesion to your cells, the first step in the process of infection.
nbprotocol.proboards.com/thread/503/nuclear-factor-kappa
~d
Iron is sequestered by cancer cells and cells infected with microbes and the presence of iron activates artimisinin's ferroptotic activity.
jhoonline.biomedcentral.com/articles/10.1186/s13045-019-0720-y
“Ferroptosis, a new form of cell death: opportunities and challenges in cancer”
“Researches indicated that ferroptosis could be triggered by diverse physiological conditions and pathological stresses in humans and animals. Ferroptosis is gradually accepted as an adaptive feature to eliminate the malignant cells. It plays a pivotal role in the depression of tumorigenesis by removing the cells that are deficient in key nutrients in the environment or damaged by infection or ambient stress”
“Ferroptosis is programmed necrosis mainly triggered by extra-mitochondrial lipid peroxidation arising from an iron-dependent ROS accretion”
Here Dr.Berg explains Reactive Oxygen Species;
Not enough iron in your system will cause cellular dysfunction like anemia and immune disregulation, too much is toxic but that would be way beyond practical limits. Iron deficiency in a person will cause artimisinin to not work as well.
Bartonella uptakes heme iron from red blood cells.
www.ncbi.nlm.nih.gov/pmc/articles/PMC95469/
“Identification, Characterization, and Functional Analysis of a Gene Encoding the Ferric Uptake Regulation Protein in Bartonella Species”
“Bartonella has an obligate heme requirement”
pubmed.ncbi.nlm.nih.gov/24151576/
"Bartonella genomes encode for 3-5 heme-binding proteins. In Bartonella henselae heme-binding proteins were shown to be involved in heme uptake process, oxidative stress response, and survival inside endothelial cells and in the flea. In this report, we discuss the use of the heme uptake and storage system of B. henselae during its infection cycle."
Taking an iron complex will feed the bartonella and will make Bartonella a target to be eliminated through ferroptosis. Also your immune system cells need iron to function well.
www.imm.ox.ac.uk/news/study-uncovers-how-low-blood-iron-diminishes-immune-response
“Study uncovers how low blood iron diminishes immune response”
In Ferroptosis cell lipids are attacked causing cell death.
www.nature.com/articles/s41419-020-2298-2
“Recent studies have shown that ferroptosis is closely related to the pathophysiological processes of many diseases, such as tumors, nervous system diseases, ischemia-reperfusion injury, kidney injury, and blood diseases. How to intervene in the occurrence and development of related diseases by regulating cell ferroptosis has become a hotspot and focus of etiological research and treatment, but the functional changes and specific molecular mechanisms of ferroptosis still need to be further explored.”
So what has come to my attention is the use of Artimisinin since Bartonella infection and cancer operate very much the same.
pubmed.ncbi.nlm.nih.gov/31114026/
“In this study, we found that artemisinin compounds can sensitize cancer cells to ferroptosis, a new form of programmed cell death driven by iron-dependent lipid peroxidation.”
The natural treatments that work against Bartonella are the ones that have anti-cancer activity because bartonella infection and cancer use the same pathways.
When I started to become interested in Bromelain I noticed that quite a few researchers were combining it with other compounds and whatever it was combined with became more effective.
One reason in this case is that Bromelain inhibits the main pathway that metabolizes Artemisinin so it stays in the blood longer and you can use a smaller dose of Artemisinin. The dose of Bromelain that you want to taper up to over a couple months is 35mg per Kg of body weight, that dose will prevent bartonella infection from advancing and that is discussed more in the link at the bottom of the page.
drbvitamins.com/products/doctor-s-best-high-potency-bromelain-3000-gdu-500-mg-90-veggie-caps-20961
pubmed.ncbi.nlm.nih.gov/18256496/
"There is limited information on the effect of fruits on human cytochrome P450 (CYP) 2C9 activity."
"Thus we found that pineapple juice was a potent inhibitor of CYP2C9, and that the inhibitory effect might be due to the bromelain contained in pineapple."
The above is called the "Bergamot Effect" and there have been warnings about grapefruit juice increasing the level of pharma drugs in the blood, but if your like me and don't believe in taking anything produced by pharma then that is nothing to worry about.
pubmed.ncbi.nlm.nih.gov/15761118/
"Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor"
"The major disadvantage of these medicines is the comparatively high recrudescence rate, which has been attributed to the remarkable decrease of artemisinin plasma concentrations during multiple dosing."
So to keep the plasma levels effective then taking it with bromelain works.
Artimisinin also shuts down NF kappa b translocation and that prevents further infection and creation of abnormal cells.
pubmed.ncbi.nlm.nih.gov/28000518/
“Then the artemisinin significantly inhibited the expression of NF-κB reporter gene induced by TNF-α in a dose-dependent manner.”
Adding this to the already Bromelain and Monolaurin based protocol will make it more effective.
This Artemisin works, when using the Bromelain and Monolaurin protocol you can take 2 capsules of the 100 mg capsule every day.You can increase that dose as you become more accustomed to it. Effectiveness is dose dependent. The target dose to work toward is 1 of 100g capsules for every 30 pounds of body weight daily.
drbvitamins.com/products/doctor-s-best-artemisinin-100-mg-90-veggie-caps-7592
When combining these items the result is an increase in effectiveness , synergy.
This Iron complex is a good one and available at quite a few sites.
www.integrativepro.com/products/iron-complex
The above strategy works well on Bartonella but you need Monolaurin to kill Borrelia and that is in the protocol as well.
www.sciencedirect.com/science/article/pii/S1084952120301993
"Given its exceptional chemical properties, iron plays an important role in numerous biochemical processes in almost all living organisms with only few exceptions such as Borrelia burgdorferi or some Lactobacilli"
pubmed.ncbi.nlm.nih.gov/26457476/
"In vitro evaluation of antibacterial activity of phytochemicals and micronutrients against Borrelia burgdorferi and Borrelia garinii"
"Conclusions: The most effective antimicrobial compounds against all morphological forms of the two tested Borrelia sp. were baicalein and monolaurin."
www.lauricidin.com/
Combining different strategies into a science based protocol is successful. When a person has these diseases and uses something that kills the infections and abnormal cells they create that will release a lot of toxins in the body and make a person feel pretty lousy. The longer you have been infected then there will be more toxins.A strong protocol will also cause this more rapidly. The NB protocol has items to address this, a whole protocol is needed to manage recovery. Read the protocol thread for that information.
One obstacle to success with a Bartonella infection is the calcification it causes which will prevent treatment penetration and that should also be addressed.
nbprotocol.proboards.com/thread/13/calcification
Read this next link to learn how to prevent bacterial adhesion to your cells, the first step in the process of infection.
nbprotocol.proboards.com/thread/503/nuclear-factor-kappa
~d